Yes, Blackjack can be played without a physical deck of cards in several ways. Online casinos offer both virtual and live-dealer Blackjack, where cards are shuffled and dealt electronically or by a live dealer. Mobile apps also allow you to play against computer-generated opponents, with the cards being simulated using algorithms. Some casinos have introduced "cardless" versions of the game, where the dealing and shuffling are handled digitally, and players interact with a virtual interface. Additionally, you can simulate Blackjack on a computer by using random number generators (RNG) to mimic the dealing of cards, which is often useful for practicing strategy. These digital formats provide a full Blackjack experience, allowing you to play and practice without the need for physical cards.