Blackjack can be profitable in the long run, especially if you use the right strategies and manage your bankroll effectively. By consistently applying basic strategy, you can reduce the house edge to around 0.5%, minimizing losses and potentially making small profits. More experienced players can increase their edge by using card counting, which can give them a 1-2% advantage over the casino. However, success in the long run also depends on good bankroll management to withstand the ups and downs of the game, as well as favorable casino conditions like game rules and payouts. While blackjack offers opportunities for profit, there are no guarantees, and risks are always involved.