Yes, blackjack can still be profitable in the long run, especially for skilled players who use techniques like card counting to gain an edge over the house. By keeping track of the deck's composition, players can adjust their bets and strategy to exploit favorable situations. However, profitability depends on factors like the casino's rules, which may include multiple decks or frequent shuffling, and the player’s ability to count cards accurately and discreetly. While blackjack offers a statistical advantage, it's still a game of variance, meaning even skilled players can experience losing streaks. Success also requires strong bankroll management and discipline to withstand these ups and downs.