Using a combination of betting systems and basic strategy in Blackjack can help manage your bankroll and make informed decisions during gameplay, but it won't change the house edge. Basic strategy minimizes mistakes by guiding decisions based on probabilities, while betting systems like Martingale or Paroli aim to manage wins and losses. However, betting systems don't influence the outcome of hands and can lead to large losses over time. Basic strategy is more reliable for optimizing play, while betting systems mainly affect how you manage your money, not the odds of winning.