To calculate the probability of winning a specific combination of numbers in a lottery game, you first determine the total number of possible combinations of numbers. This involves using combinatorial mathematics to find how many ways the chosen numbers can be arranged. Then, calculate the probability by dividing 1 by the total number of possible combinations. This gives the likelihood of your specific combination being drawn. For example, in a game where you select 6 numbers from a pool of 49, you would calculate the total possible combinations and then find the probability of matching all 6 numbers exactly.