Betting the run line can make more sense than the moneyline in a scenario where a strong favorite is facing a significantly weaker opponent, and the starting pitcher for the favorite is dominant. For instance, if Team A, featuring an ace pitcher with an excellent track record, is playing against Team B, which has a struggling pitcher and a depleted lineup, the moneyline odds for Team A might be prohibitively low (e.g., -250). Betting on Team A to cover the -1.5 run line could offer better value, particularly if Team A is likely to win comfortably by two or more runs, thereby maximizing potential returns while mitigating the high cost of betting the outright win.