I think is possible that some gamers may be able to discern a new gambling setup, especially if they are familiar with the game and its rules. They may be able to recognize a change in the number of players, the type of bets allowed, or the specific rules of the game. Additionally, some gamers may be able to detect strategies or behaviors used by other players that indicate a change in the setup. Overall, the ability to discern a new gambling setup may depend on a variety of factors, including the individual's experience with gambling and their knowledge of the particular game being played.