The payout rates of slot machines are not determined by the day of the week, including weekends. Casino operators set the payout percentages for their slot machines, which are programmed to pay out a specific return over time, regardless of when they are played. However, some players believe that machines might pay more during busy times, like weekends, due to the higher volume of players. This perception may stem from the excitement and ambiance of a crowded casino, but in reality, the odds remain consistent regardless of the day.