Players can leverage their knowledge of house rules to their advantage by choosing games or tables that offer more favorable conditions, such as better payout ratios, fewer decks, or specific rules like the dealer standing on soft 17. Understanding the house rules allows players to adjust their strategies, such as when to split or double down, in ways that reduce the house edge. Familiarity with rules also helps players avoid mistakes and make decisions that maximize their chances of winning over the long term.