Minimizing losses while playing blackjack involves a combination of strategic decision-making and disciplined bankroll management. Adopting optimal playing strategies, such as basic strategy charts, can help guide decisions based on statistical probabilities, reducing the house edge, managing your bankroll effectively by setting limits on both wins and losses, as well as spacing out bets, aids in preventing significant financial setbacks. It's also crucial to avoid emotional reactions and maintain a calm and focused mindset, which helps prevent impulsive decisions that could lead to larger losses. Lastly, choosing games with favorable rules and fewer decks can further enhance chances of minimizing losses over time.