Different casino rules can significantly influence the odds and strategies in blackjack. Variations such as the number of decks used, whether the dealer hits or stands on a soft 17, and the payout for blackjack (3:2 versus 6:5) play a crucial role in shaping the house edge. Additional factors, such as the ability to double down or split pairs, and specific house rules regarding surrender, can also affect optimal strategies and the overall expected return for players.