Slot machine payouts at different casinos can vary significantly due to several factors, including the establishment's location, type of machines offered, and the casino's operational policies. Typically, casinos must adhere to state regulations that dictate minimum payout percentages, which can lead to differences in average returns across various jurisdictions. Additionally, larger resorts or casinos may have a wider selection of machines with different payout structures, from penny slots to high-limit options. Factors like machine denomination, theme, and game design also influence payout rates.