To use a probability calculator to analyze lottery games, input the total number of possible outcomes and the number of outcomes you're selecting. For example, in a 6/49 lottery, you would enter 49 as the total number of possible numbers and 6 as the number of selections. The calculator then computes the probability of matching various combinations, such as two, three, or all six numbers. This helps you understand the odds of winning different prize tiers. Probability calculators can also be used to explore different lottery formats and compare your chances of winning across multiple games.