Inside bets and outside bets differ significantly in terms of risk and reward in roulette. Inside bets are placed on specific numbers or small groups of numbers, offering higher payouts when successful, usually ranging from 5 to 35 times the bet amount. However, these bets come with a lower probability of winning, making them riskier. Conversely, outside bets involve larger groups of numbers, such as red or black, or odd or even, leading to lower payouts, typically between 1 to 2 times the bet amount.