Sportsbooks set the run line odds by considering various factors, including the relative strengths and weaknesses of the competing teams, starting pitchers, historical performance, and public betting patterns. The run line is typically set at -1.5 for the favorite and +1.5 for the underdog, with the odds for these spreads adjusted to reflect the perceived likelihood of each outcome. For example, a strong favorite may have run line odds of around -110 to -130, indicating a competitive edge while still offering value for a two-run victory.