When multiple decks are used in Blackjack, the odds of getting a Blackjack slightly decrease because there are more cards in play, reducing the proportion of Aces and ten-point cards. For example, in a single-deck game, the odds are about 4.8%, while in a six-deck game, they drop to around 4.75%. Overall, using more decks tends to reduce the player's advantage and slightly favors the house.