The odds in Blackjack change when more than one deck is used, with the house edge generally increasing as more decks are added. In single-deck games, players have a slight advantage, especially with perfect strategy, because it's easier to track cards and the chances of getting a Blackjack are higher. As more decks are introduced, the composition of the deck becomes harder to track, reducing the player's ability to predict outcomes. With multiple decks, the likelihood of getting a Blackjack decreases, and card counting becomes less effective, resulting in a higher house edge. In games with six or eight decks, the house edge typically rises to around 0.6%-0.7%. Overall, more decks slightly favor the house, making the game less advantageous for players.