When facing a player using a GTO (Game Theory Optimal) strategy, the key to adjusting is to exploit the small imperfections in their play, even if their strategy is theoretically balanced. Since GTO is designed to make you indifferent to their decisions, you want to look for opportunities where they might deviate from their ideal play due to human tendencies or slight miscalculations. One adjustment is to focus on exploiting their mistakes in specific situations, such as when they make predictable bets or mismanage bet sizing. Additionally, varying your own play can throw off their calculations, forcing them to deviate from the optimal strategy in response. This means mixing up your betting patterns, bluffing frequencies, and hand selections to make it difficult for them to counter your moves with the same consistency. Over time, you can also try to identify and capitalize on the adjustments they make in response to your play, which could open up further exploitable opportunities. It’s important to remain unpredictable, making it hard for them to maintain the efficiency of their GTO strategy.