Your strategy should become tighter in early positions, focusing on stronger hands, as you have to act without seeing how others will play. In middle positions, you can start to widen your range slightly since you'll have more information on early actions. In late positions, you can play more aggressively and take advantage of weaker or cautious opponents, using position to pressure them. Your position impacts the strength required to open, call, or raise, and having position post-flop allows for better control of the pot, making bluffs and semi-bluffs more effective. This adaptability is key to maximizing profits and minimizing risks.