To calculate the potential payout of a winning point spread bet, you start by determining the amount of your wager and the odds associated with the bet, which is typically presented in the format of negative odds for point spread bets. This means you would need to wager a specific amount to win a smaller amount. To calculate your potential payout, first, you consider your stake and then determine your profit based on the odds. If your team covers the spread, you would receive your original wager back plus an additional amount based on your profit, resulting in a total payout that includes both your initial stake and your winnings.