To exploit opponents who play too many hands, you can adjust your strategy to take advantage of their loose and aggressive play. This involves being more selective with your starting hands, waiting for stronger hands to play against their weaker range. You can also use their aggression against them by trapping with strong hands, allowing them to commit chips to the pot with weaker hands. Additionally, you can use their tendency to play many hands to bluff less frequently, as they are more likely to call with weaker hands. By playing more patiently and selectively, you can capitalize on their mistakes and build a significant edge.