To handle an opponent who never folds, focus on playing strong hands and avoiding bluffs. Maximize value by betting aggressively when you have a good hand, knowing they are likely to call. Adjust your range to include more value hands and fewer speculative ones since their willingness to call makes drawing hands riskier. Control the pot size with marginal hands, keeping it smaller to avoid unnecessary risks. Prioritize hands that can stand up to pressure, as they’ll likely pay off even if they have weaker holdings.