Playing medium pairs pre-flop requires a balance between aggression and caution. In early position, it's usually best to play cautiously, often opting for a call or a small raise to control the pot size. In middle or late position, medium pairs are stronger, and a raise can help isolate opponents and take control of the hand. If there are raises ahead, calling is often a good choice, especially if the pot odds are favorable for potentially hitting a set. Against multiple opponents, medium pairs can be profitable due to the potential to win a big pot if you hit a strong hand on the flop. However, if facing aggressive action, folding may be the best option to avoid tricky spots later in the hand.