When holding pocket Aces pre-flop against multiple opponents, aim to maximize value while protecting your hand from too many callers. Start by raising enough to thin the field without pushing everyone out, as a larger field increases the risk of another player hitting a strong draw or set. If raised, consider re-raising to establish strength, but remain cautious of players who persist, as they may have premium hands themselves. Adjust your strategy based on stack sizes, opponent tendencies, and position, balancing between maximizing your winnings and minimizing risks.