The 6:5 Blackjack payout significantly increases the house edge compared to the traditional 3:2 payout. With 6:5, you earn less money for hitting a Blackjack, which reduces your overall winnings and increases the house's advantage. This change typically raises the house edge from around 0.5% to about 1.4% or more, meaning you'll lose more money over time. While basic strategy remains the same, the lower payout results in a worse expected return, making the game less favorable for players.