When multiple winners hit on the same machine, the casino typically processes each win separately, ensuring that each player's payout is handled according to the machine's payout rules. If the wins are from different players during the same spin or round, each player will receive their respective winnings based on the game’s rules and the amount wagered. In the case of a large jackpot, the casino may have protocols in place to verify and process the payout, ensuring that no discrepancies arise.