Multi-way action significantly changes your pre-flop strategy by increasing the complexity and unpredictability of the hand. With multiple opponents, the likelihood of someone having a strong hand increases, making it more important to be selective with your starting hands. Additionally, multi-way pots often lead to more aggressive and unpredictable post-flop play, requiring you to be more cautious and adaptable in your decision-making. This may involve tightening up your starting hand selection, avoiding marginal hands, and being prepared to fold to aggression or strong hands.