Adjusting to increasing aggression in the middle stages of a PLO tournament requires tightening hand selection, leveraging position, and exploiting overly aggressive opponents. Recognizing which players are applying pressure for chip accumulation and which are making reckless moves helps in countering their strategies effectively. Playing hands with strong postflop equity ensures the ability to withstand aggression while avoiding unnecessary high-variance spots. Well-timed re-raises and traps can turn opponents' aggression against them, forcing them into difficult decisions.