The number of decks in play significantly impacts the optimal strategy in games like blackjack. Generally, as the number of decks increases, the player's advantage decreases due to a dilution of card tracking. In single-deck games, players can make more precise decisions based on remaining cards, enhancing strategies like card counting. With multiple decks, the likelihood of receiving favorable cards, such as aces or ten-value cards, diminishes, making certain strategies less effective. Consequently, players may need to adjust their betting and playing strategies to account for the increased house edge in games with more decks, often requiring more conservative approaches as the number of decks rises.