The payout for blackjack significantly affects your strategy because it changes the overall return on your bet. A 3:2 payout for a blackjack is more favorable, providing a better long-term value, while a 6:5 payout reduces the payout and increases the house edge, making the game less profitable for players. This means you may need to adjust your bet size or seek out 3:2 games to minimize losses. Card counters, in particular, may find that the lower payout on 6:5 tables reduces the effectiveness of their strategy, making these games less appealing. Overall, while basic strategy remains the same, the reduced payout in 6:5 games shifts the odds, making it more important to prioritize tables offering the better 3:2 payout.