The amount you can expect to win or lose per hour in blackjack depends on factors like the house edge, your bet size, and how many hands you play. With a typical house edge of around 0.5% when using basic strategy, the average loss would be around $7.80 per hour if you're betting $25 per hand and playing 60 hands. If you increase your bet size to $100 per hand, the expected loss could rise to around $30 per hour. However, variance can cause significant swings in the short term, and card counting, if done successfully, can improve your odds and potentially lead to small wins instead of losses.