When playing against multiple aggressive players, a player should adjust their strategy by being more selective with hand choices and focusing on solid fundamentals. It's essential to avoid getting caught up in aggressive betting patterns and to maintain a disciplined approach. Instead of trying to out-aggress the opponents, players should consider playing tighter and waiting for strong hands to exploit their opponents' over-aggressiveness. Utilizing position effectively is also crucial, as it allows for better decision-making in response to aggressive actions.