Effective flop play in PLO revolves around assessing your hand's strength and potential, considering the board texture and opponents' ranges. Players should prioritize playing strong hands and draws aggressively, while controlling the pot with weaker holdings. Understanding board coverage, recognizing nut advantage, and accurately estimating implied odds are crucial for making profitable decisions. Aggressive betting with strong hands and draws, coupled with strategic check-raising and pot control, forms the foundation of a successful PLO flop strategy.