Heads-up PLO play requires aggression, adaptability, and an emphasis on position. Since hand values decrease in relative strength, widening ranges and playing more hands in position is crucial. Betting and raising frequently apply pressure, forcing opponents into difficult spots. Bluffing and semi-bluffing become more effective due to increased fold equity, but balanced play is necessary to avoid predictability. Hand reading and adjusting to opponent tendencies play a major role, as exploiting weaknesses in aggression or passivity can shift the momentum.