In multi-way PLO pots, strategic considerations revolve around hand strength, position, equity distribution, and future street playability. Since equities run closer in Omaha, absolute hand strength is less important than relative strength against multiple opponents. Position is crucial for extracting value and controlling pot size, as betting in early position can lead to uncomfortable spots when multiple players remain. The presence of multiple opponents increases the likelihood of strong hands and draws, making it essential to favor hands with nut potential and redraws.