Heads-up play requires a more aggressive and adaptive strategy, as every hand is a battle for blinds, demanding wider ranges and frequent adjustments. With only one opponent, reading tendencies and exploiting weaknesses become more direct, making psychological factors crucial. Multi-way play, in contrast, emphasizes pot control, selective aggression, and hand strength due to the increased likelihood of facing strong holdings. Bluffing is riskier with multiple opponents, and position becomes even more significant in determining optimal decision-making.