No-Limit Hold’em (NLH) and Pot-Limit Omaha (PLO) differ fundamentally in hand strength, variance, and strategy. PLO’s four-hole-card structure creates more possibilities, making pre-flop equities run closer and reducing the dominance of premium hands. This leads to stronger post-flop play, emphasizing drawing hands and nut potential. The pot-limit betting structure in PLO controls aggression compared to NLH’s all-in dynamics, requiring more calculated risk-taking.