Texas Hold’em and Omaha differ primarily in the number of hole cards, hand selection strategies, and the strength of winning hands. In Hold’em, players receive two hole cards and can use any combination with the community cards, allowing for a wider range of playable hands. Omaha deals four hole cards, requiring players to use exactly two in combination with three community cards, leading to more complex decision-making and stronger hands at showdown. The increased possibilities in Omaha create a higher variance game, demanding a greater emphasis on drawing potential and board texture awareness.