Pot-Limit Omaha requires cautious starting hand selection, focusing on hands with strong potential and multiple possibilities. Position is critical, as playing later in the betting rounds allows for better assessment of opponents' intentions. It's essential to avoid overcommitting with mediocre hands since strong combinations are more frequent. Emphasizing drawing to the nuts is crucial, as lower-ranked hands are often vulnerable. Betting size control is key, managing the pot to avoid risking too much without a solid advantage. Reading the board accurately and adapting to changing dynamics helps maintain an edge, as situations can shift rapidly with the game's structure.