The most profitable bluffing spots in Texas Hold'em are often situations where your opponent is likely to fold to aggression, and where the board texture and your table image support the credibility of your bluff. These spots often arise on the river, particularly when the board has run out in a way that makes it unlikely for your opponent to have a strong hand, and when your opponent has shown weakness or hesitation throughout the hand. Additionally, bluffing on the turn can also be profitable, especially when the board has paired or when you have a strong range advantage.