The odds of winning a Blackjack hand depend on factors like the rules of the game and the number of decks in use. In a standard 6-deck game with basic strategy, players can expect to win around 42-44% of the time, with losses occurring about 47-49% of the time and ties (pushes) around 8-9%. The odds of getting a Blackjack (a natural 21) are roughly 4.75%. While the number of decks influences the house edge, single-deck games typically offer slightly better odds for players, though they often come with stricter rules that balance out the advantage. Overall, Blackjack remains a game of chance with outcomes varying over the short term.