With an open-ended straight draw and no pair on the flop, your goal is to evaluate the potential profitability of continuing. Consider factors like pot odds, implied odds, and the actions of opponents. If the bet size is manageable compared to the pot and your draw odds are favorable, calling or even semi-bluffing could be viable. In multiway pots, playing more cautiously is wise, while heads-up situations may allow for a more aggressive approach. Pay close attention to position, as acting last provides valuable information and increases flexibility in deciding whether to pursue or fold.