The best strategy for playing Blackjack revolves around making decisions based on your hand value and the dealer's upcard while minimizing losses and maximizing potential gains. Fundamental strategies suggest standing on a total of 17 or higher, hitting on lower totals depending on the dealer's card, and doubling down when you have strong starting hands like 10 or 11 against a weaker dealer card. When facing a pair, consider splitting to increase your chances of winning, particularly with Aces and 8s.