The best way to use pot odds in decision-making involves comparing the size of the pot to the cost of a potential call to determine whether it's profitable in the long run. To make a decision, you first calculate the pot odds—what you stand to win versus what you must risk—and compare them to the odds of completing your drawing hand. If the pot odds are greater than or equal to the odds of hitting your hand, calling becomes a profitable choice. This method helps to ensure that you're making mathematically sound decisions, avoiding calls that would lose money over time, and capitalizing on situations where your potential reward outweighs the cost of a bet.