The difference between "21" and Blackjack lies in the specifics of the hand. "21" refers to any hand that totals 21 points, which can be achieved with two or more cards. However, "Blackjack" is a particular type of 21-point hand, consisting of an Ace and a 10-point card (10, Jack, Queen, or King) dealt as the first two cards. A Blackjack is the highest possible hand and usually pays out at 3:2, whereas a hand that totals 21 from more than two cards pays out at 1:1.