The primary difference between a point spread bet and a run line bet in baseball lies in the scoring system that each bet applies. In point spread betting, commonly used in sports like football and basketball, a team must win by a certain number of points (the spread) for a bet on them to be successful. Conversely, the run line in baseball is typically set at 1.5 runs, meaning the favored team must win by at least two runs to cover the spread, while the underdog can either win outright or lose by one run to cover. This nuanced difference reflects the nature of scoring in baseball, where games can frequently end with narrow margins, making run line betting a unique and popular option among baseball bettors.