Moneyline and spread betting are two different types of wagers used in sports betting. The main difference lies in how the outcome of the game is determined and how the betting odds are set. Moneyline betting focuses on which team will win the game outright, with payouts based on the odds assigned to each team's chances of winning. Spread betting, on the other hand, involves predicting whether the actual score will be above or below a given point spread set by the bookmaker, with the goal of beating the spread rather than betting on the outright winner.