To mitigate losses during unfavorable probabilities, players can adopt several strategies. One effective approach is implementing a strict bankroll management system, where they set limits on how much they are willing to lose in a session and adhere to those limits. Adjusting bet sizes based on current gameplay and the level of risk can help preserve funds during challenging situations. Players can also focus on employing basic strategy to minimize the house edge, making optimal decisions based on the statistical probabilities of their hands.