Edward O. Thorp, Ken Uston, and the MIT Blackjack Team are among the most famous professional blackjack players, each leaving a lasting impact on the game. Thorp pioneered card counting, showing it was possible to gain an edge over the house. Uston popularized team play and advanced counting techniques, prompting casinos to adjust game setups. The MIT Blackjack Team mastered team-based counting, winning millions and inspiring both public intrigue and stricter casino security. Their innovations reshaped blackjack strategy and influenced the evolution of casino practices.