Captain Sarah Hunter will retire after England's opening Women's Six Nations match against Scotland in her home city of Newcastle on Saturday.
The back-row forward, 37, is the world's most-capped women's player with 140 caps, and is also England's most-capped player, male or female.
Since her debut in 2007, Hunter has won one World Cup and 10 Six Nations titles, including nine Grand Slams.
"The RFU kindly put a Red Roses game finally at Newcastle, which is my home city where I grew up. I just couldn't not give it a go to play in the game.
The back-row forward, 37, is the world's most-capped women's player with 140 caps, and is also England's most-capped player, male or female.
Since her debut in 2007, Hunter has won one World Cup and 10 Six Nations titles, including nine Grand Slams.
"The RFU kindly put a Red Roses game finally at Newcastle, which is my home city where I grew up. I just couldn't not give it a go to play in the game.